DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Vision - A time when the causative links between Traumatic Brain Injury and epilepsy are understood and Post-Traumatic Epilepsy is both preventable and treatable

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Epilepsy Research Program Cover Image
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The ERP was initiated in 2015 to develop an understanding of the magnitude of post-traumatic epilepsy (PTE) within the military and to expand research into the basic mechanisms by which traumatic brain injury (TBI) produces epilepsy. To this end, and to satisfy the ERP's Mission and Vision, the ERP has identified the following research Focus Areas for FY18:

  • Epidemiology: Epidemiological characterization of PTE following TBI, which may include the following:
    • Risk factors such as demographics, genetic factors, organic head injury factors, or type of insult
    • Differentiation of PTE and psychogenic non-epileptic seizures (PNES)
    • Outcomes including latency to epilepsy, morbidities and comorbidities, and mortality
    • Pre-existing conditions including psychological and psychiatric risk factors
    • Treatment

    Note: Applications proposing epidemiological research should be submitted under the Epidemiology Option.

  • Markers and Mechanisms: Identifying markers or mechanisms (via clinical prospective or preclinical models) that address PTE, which may include the following:
    • Early detection
    • Diagnosis
    • Prognosis
    • Morbidity
    • Comorbidity
    • Mortality
    • Risk stratification

  • Note: Research considering the development of new models or better characterization of existing etiologically relevant models for PTE, including repetitive TBI, could be considered under this Focus Area.

    Longitudinal Studies: Studies of the natural evolution of PTE, which may include the following:
    • Seizure frequency and severity
    • Comorbidities (e.g., depression, functional deficits, sleep disorders, major illness)
    • Latency between injury and PTE
    • Mortality
    • Treatment
    • Quality of life of individuals with PTE


Congressional Appropriations

Congressional Appropriations

  • $22.5 million
    FY15-17
  • $7.5 million
    FY18

...

Funding
Summary


Related Videos

Dr. Karen Parko

Department of Veterans Affairs, Epilepsy Centers of Excellence
Resolving the Connection Between TBIs and Epilepsy

Jay Hennessy

Epilepsy Foundation of Florida
A Consumer’s Perspective: Two Minutes Could Change Your Life

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Vision

A time when the causative links between Traumatic Brain Injury and epilepsy are understood and Post-Traumatic Epilepsy is both preventable and treatable

Mission

To advance research towards understanding the mechanisms underlying the genesis and progression of Post-Traumatic Epilepsy, especially in Service members and Veterans

Last updated Friday, October 12, 2018