DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

In an effort to facilitate collaborations and speed GWI research, the GWIRP has compiled a list of various research resources produced from our funding. The list displays available resources and contact information. Please contact the PI(s) directly for information and requests.

Animal Models
Award Number PI Model References Contact Information

GW060050

Mariana Morris

Low dose sarin exposure in mice

Oswal DP, Garrett TL, Morris M, et al. 2013. Low-dose sarin exposure produces long term changes in brain neurochemistry of mice. Neurochem Res 38(1):108-116.

mmorris1@nova.edu

GW080102

Mohamed Abou Donia

Rats dermally exposed to DEET and permthrin

Abdel-Rahman, A.A., Shetty, A.K. and Abou-Donia, M.B (2001). Sub-chronic dermal application of N,N- diethyl-m-toluamide (DEET) and permethrin to adult rats, alone and in combination, causes diffused neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss in cerebellum. Exp. Neurol. 172: 153-171. [Model established prior to GWIRP funding but reproduced and confirmed with the GWIRP award.]

donia@dm.duke.edu

GW080094,

GW100076

Fiona Crawford and Ghania Ait-Ghezala

Pyridostigmine Bromide and permethrin in mice

Ojo JO, Abdullah L, Evans J, et al. 2014. Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure. Neuropathology 34(2):109-127.                                                              

Zakirova Z, Tweed M, Crynen G, et al. 2015. Gulf war agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of gulf war illness. PLoS One. 10(3):e0119579.

Zakirova Z, Crynen G, Hassan S, Abdullah L, Horne L, Mathura V, Crawford F, Ait-Ghezala G. A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure. Front Integr Neurosci. 2016 Jan 12;9:71. doi: 10.3389/fnint.2015.00071.

eCollection 2015. PubMed PMID: 26793076; PubMed Central PMCID: PMC4709860.

fcrawford@rfdn.org

gaitghezala@rfdn.org

GW080150

Stephen Lasley and James O'Callaghan

DFP treatment preceded by corticosterone in mice

O'Callaghan JP, Kelly KA, Locker AR, Miller DB, Lasley SM. 2015. Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness. J Neurochem 133(5):708-721

sml@uic.edu

jdo5@cdc.gov

GW093021

John Repine

Inhalation methodology

Repine JE, Wilson P, Elkins N,et al. 2016. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 51(6):366-73.

john.repine@ucdenver.edu

GW110073

Alvin Terry

Repeated exposure to chlorpyrifos

Hernandez CM, Beck WD, Naughton SX, et al. 2015. Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain. Neurotoxicology 47C:17-26.

aterry@augusta.edu

GW100022

GW120039

GW140066

Brian Cooper

DEET, Permethrin, chlorpyrifos, with or without pyridostigmine bromide (PB), with pain behaviors

Nutter, T.J., Johnson, R.D. and Cooper, B.Y. A Delayed Chronic Pain Like Condition with Decreased Kv Channel Activity in a Rat Model of Gulf War Illness Pain Syndrome. NeuroToxicology 51 (2015) 67–79.

bcooper@dental.ufl.edu

Last updated Tuesday, November 7, 2017