DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Vision - Decrease the clinical impact of neurofibromatosis

Neurofibromatosis Cover Image

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Neurofibromatosis (NF) is a group of three genetically distinct disorders that cause tumors to grow in the nervous system. It also produces other abnormalities in the skin and bones. There are three types of NF: 1) NF 1 affects 1 in 3,500 people worldwide and is caused by a mutation in the neurofibromin gene, 2) NF2 affects 1 in 25,000 people and is caused by mutations in the Merlin gene, 3) Schwannomatosis is much rarer, affecting 1 in 40,000 people, and although mutations in the SMARCB1/INI1 gene have been associated with the disease, we do not fully understand the underlying cause to many of the symptoms of the disorder. The Neurofibromatosis Research Program (NFRP) was established in 1996 when the efforts of NF advocates led to a congressional appropriation to fund research in NF.

Update February 2016:
The NFRP Peer Review and Programmatic Review meetings have concluded, and the investigators for the projects to be funded in FY15 have been notified of the status of their awards. The NFRP team at CDMRP, along with contract support staff and various offices at the DoD, will be hard at work in the coming months to make the awards happen! We are thrilled about the exciting projects to be funded by our program this year.

Be on the lookout for program announcements for funding opportunities in the coming months! A pre-announcement of what to look forward to in FY16 can be found at this link.

Please follow the links in the left panel of this page to visit some highlights and efforts by the NFRP and those that support it. Additional information regarding resources funded by the NFRP available to all researchers, and our program history can also be found on this page.


Congressional Appropriations

Congressional Appropriations

  • $272.85 million
    FY96-FY14
  • $15.0 million
    FY15

Funding Summary

Funding
Summary


NFRP Supported Initiatives

news_icon News & Highlights

Vision

Decrease the clinical impact of neurofibromatosis

Mission

Promote research directed toward the understanding, diagnosis, and treatment of NF1, NF2 and schwannomatosis to enhance the quality of life for persons with those diseases.


Last updated Friday April 22 2016