DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Overview | Consortium History | Management and Oversight | Research Site Details | Approved Trial Details

The Neurofibromatosis Clinical Trials Consortium (NFCTC, http://www.uab.edu/nfconsortium) was established by the Department of Defense Neurofibromatosis Research Program (NFRP) to develop and perform clinical trials for the treatment of neurofibromatosis (NF) complications in children and adults. The Consortium is composed of thirteen clinical sites, six collaborating sites, and an Operations Center at the University of Alabama at Birmingham under the direction of Dr. Bruce Korf. The purpose of the Operations Center is to provide administrative, data management, and statistical support to the NFCTC. Each of the clinical and collaborating sites has expertise in the treatment and management of NF and an established patient population available for clinical trials.

Approved NFCTC Clinical Trials (FY06 NFRP Award)

(1) STOPN: Sirolimus for the Treatment of NF1-Related Plexiform Neurofibromas
(2) STARS: Lovastatin for the Treatment of Learning Disabilities in Children with NF1
(3) RAD001: RAD001 for Children with NF1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas
(4) MPNST: RAD001 in Combination with Bevacizumab for Patients with Sporadic and NF1-Related Refractory MPNST (Collaboration with the Sarcoma Alliance for Research through Collaboration (SARC))

Approved NFCTC Clinical Trials (FY11 NFRP Award)

(1) Bevacizumab for NF2-Related Progressive Vestibular Schwannomas
(2) Cabozantinib (XL184) for NF1-Related Plexiform Neurofibromas
(3) PD-0325901 for NF1-Related Plexiform Neurofibromas
(4) INFUSE Bone Graft for treatment of NF1-Related Tibial Pseudarthrosis
(5) Phase I/II Trial of Ganetespib in Combination with Sirolimus for Patients with Refractory MPNST (Collaboration with SARC)
(6) Phase I/II Study of MEK162 for Children with Low-Grade Gliomas and Other Ras/Raf/MAP Pathway Activated Tumors (Collaboration with non-consortium sites for the NF1-specific cohort)

Consortium Sites
(As listed on http://www.uab.edu/nfconsortium/sites)

Operations Center
University of Alabama at Birmingham

Sites
Boston/Harvard Center for NF and Allied Disorders
Children's Hospital at Westmead, University of Sydney
Children's Hospital of Los Angeles
Children's National Medical Center
Cincinnati Children's Hospital Medical Center
Indiana University
National Cancer Institute
New York University Medical Center
University of Alabama at Birmingham
University of Chicago
University of Pennsylvania
University of Utah
Washington University

Affiliate Sites
Ann & Robert H. Lurie Children's Hospital of Chicago
Children’s Healthcare of Atlanta
Johns Hopkins Hospital
Massachusetts General Hospital
Royal Children’s Hospital
Texas Scottish Rite Hospital


Last updated Thursday, May 18, 2017