Vision - Decrease the clinical impact of neurofibromatosis

Neurofibromatosis Cover Image

» Click on Image to View Program Booklet

Neurofibromatosis (NF) is a group of three genetically distinct disorders that cause tumors to grow in the nervous system. It also produces other abnormalities in the skin and bones. There are three types of NF: 1) NF 1 affects 1 in 3,500 people worldwide and is caused by a mutation in the neurofibromin gene, 2) NF2 affects 1 in 25,000 people and is caused by mutations in the Merlin gene, 3) Schwannomatosis is much rarer, affecting 1 in 40,000 people, and although mutations in the SMARCB1/INI1 gene have been associated with the disease, we do not fully understand the underlying cause to many of the symptoms of the disorder. The Neurofibromatosis Research Program (NFRP) was established in 1996 when the efforts of NF advocates led to a congressional appropriation to fund research in NF.

Updated April 2018:
The NFRP Peer Review and Programmatic Review meetings have concluded, and the investigators who submitted applications for FY17 have been notified of the status of their awards. We are thrilled about the exciting projects to be funded by our program this year. To view a list of FY17 awardees recommended for funding, please see the link in the panel on the left.

Be on the lookout for upcoming Program Announcements! A link to the funding opportunities that we have planned can be found to left. We have a new funding mechanism focusing on early stage investigators; please check out the details in the pre-announcement!

Please follow the links in the left panel of this page to visit some highlights and efforts by the NFRP and those that support it. Additional information regarding resources funded by the NFRP available to all researchers, and our program history can also be found on this page.

Congressional Appropriations

Congressional Appropriations

  • $302.9 million
  • $15.0 million

Funding Summary


NFRP Supported Initiatives

Related Videos

Dr. Douglas Miller

University of Missouri School of Medicine
Confronting the Challenge of Neurofibromatosis

news_icon News & Highlights


Decrease the clinical impact of neurofibromatosis


Promote research directed toward the understanding, diagnosis, and treatment of NF1, NF2 and schwannomatosis to enhance the quality of life for persons with these disorders that impact Service members, Veterans, and the general public

Last updated Wednesday, May 16, 2018