Vision - Decrease the clinical impact of neurofibromatosis

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Neurofibromatosis (NF) is a group of three genetically distinct disorders that cause tumors to grow in the nervous system. It also produces other abnormalities in the skin and bones. There are three types of NF: 1) NF 1 affects 1 in 3500 people worldwide and is caused by a mutation in the neurofibromin gene, 2) NF2 affects 1 in 25,000 people and is caused by mutations in the Merlin gene, 3) Schwannomatosis is much rarer, affecting 1 in 40,000 people, and although mutations in the SMARCB1/INI1 gene have been associated with the disease, we do not fully understand the underlying cause to many of the symptoms of the disorder. The Neurofibromatosis Research Program (NFRP) was established in 1996 when the efforts of NF advocates led to a congressional appropriation to fund research in NF.

Update October 2015:
The CDMRP award process relies on valuable input from consumer advocates, scientific peer reviewers, integration panels, principle investigators and their institutions, contract support staff and various offices here at the DOD (visit this link for additional information). We are very pleased to announce that due to the efforts of these individuals, all Fiscal Year (FY) 2014 NFRP awards have been made! The research planned under these awards range from exciting new ideas that may be risky but have potential for the greatest impact if successful, to large multicenter clinical trials that will test promising treatments for people with NF.

This Fall on the NFRP website, we will be highlighting our New Investigator Award (NIA) mechanism. A highlight of the actual award mechanism will be posted on the main CDRMP webpage beginning October 9, and will also be accessible on this page in the right-hand panel under "Research Highlights." We will also highlight the research accomplishments of two NIA recipients, one former recipient and one investigator with current NIA funding. Please visit the main CDMRP and NFRP webpages regularly to read about the exciting research funded by CDMRP, past and current.

Please follow the links in the right panels of this page to visit some highlights and efforts by the NFRP and those that support it. Additional information regarding resources funded by the NFRP available to all researchers, and our program history can be found on this page.

Congressional Appropriations

Congressional Appropriations

  • $272.85 million
  • $15.0 million

Funding Summary


NFRP Supported Initiatives

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Decrease the clinical impact of neurofibromatosis


Promote research directed toward the understanding, diagnosis, and treatment of NF1, NF2 and schwannomatosis to enhance the quality of life for persons with those diseases.

Last updated Tuesday January 19 2016