Research Resources Initiative by the NFRP

The NFRP now offers a service on our website featuring a listing of available NF research resources!! Our goal is to facilitate and speed NF research by publicizing new resources and aiding collaborations. The list displays available resources and repository or PI contact information. Please contact the repository or PI directly for information and requests.

Mouse Models
Award Number	PI	Product or Resource	References	Contact Information or Link
NF093053	Nancy Ratner	PlpCre;Nf1 flox/flox	Mayes D.A., Rizvi T, Canselas J, et al. 2011 Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer Research 71(13):1-11.	Please contact both Drs. Nancy Ratner (nancy.ratner@cchmc.org) and Luis Parada (luis.parada@utsouthwestern.edu).
NF080017	Florent Elefteriou	Nf1 loss of function in chondrocytes	Wang W, et al. 2011. Mice lacking Nf1 in osteochondroprogenitor cells displays skeletal dysplasia similar to patients with neurofibromatosis type 1. Human Molecular Genetics 20(20):3910-3924.	florent.elefteriou@vanderbilt.edu
NF073112	Feng-Chun Yang	NF1 skeletal model with reduced bone mineral density, reduced calcium ossification, reduced bone turnover, and increased ratio of spinal canal area to vertebral body area	Xiaohua W, et al. 2011. The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis Type 1. Public Library of Science 6(9):e24917. doi.10.1371/journal.pone. 0024917	fyang@iupui.edu
NF043040 NF043050	Andrea McClatchey	Model of renal carcinoma: Vil-Cre; Nf2^lox/lox	Morris ZS and McClatchey AI. 2009. Aberrant epithelial morphology and persistent EGFR signaling in a mouse model of renal cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America 106(24):976-982.	mcclatch@helix.mgh.harvard.edu
NF043050 NF010093	Tyler Jacks	Paternal inheritance of Nestin-Cre resulting in mosaic loss of Nf2: NesCre^P; Nf2^flox/flox	McLaughlin ME et al. 2007. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proceedings of the National Academy of Sciences of the United States of America 104(9):3261-3266.	tjacks@mit.edu
NF010093 NF990018	Kevin Shannon	Model of myeloproliferative disorder: Mx1-Cre; Nf1^flox/flox	Le DT et al. 2004. Somatic inactivation of NF1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood 103(11):4243-4250.	ShannonK@peds.ucsf.edu
NF010016	Marco Giovannini	Protein 4.1B^flox/flox Protein 4.1B^+/- Protein 4.1B^-/-		mgiovannini@hei.org
NF990018 NF960044	Luis Parada	Conditional knockout of Nf1: Nf1 ^flox/flox Conditional knockout of Nf1 in neurons: Synapsin 1-Cre; Nf1^flox/flox	Zhu Y et al. 2001. Ablation of NF1 function in neurons induces abnormal brain development of cerebral cortex and reactive gliosis in the brain. Genes & Development 15(7):859-876.	http://mouse.ncifcrf.gov/available_details.asp?ID=01XM4 (external link)
NF960044	Luis Parada	Nf1^+/-; p53+/- cis	Cichowski K et al. 1999. Mouse models of tumor development in neurofibromatosis type 1. Science 286(5447):2172-2176.	http://jaxmice.jax.org/strain/008191.html (external link)
NF960041	Tyler Jacks	Nf1^+/-; p53+/- cis	Vogel KS et al. 1999. Mouse tumor model for neurofibromatosis type 1. Science 286(5447):2176-2179.	http://jaxmice.jax.org/strain/008191.html (external link)
NF960041	Tyler Jacks	Model of glioblastoma: Nf1 ^+/-; Trp53 ^+/-	Reilly KM et al. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genetics 26(1):109-113.	tjacks@mit.edu
NF960041	Tyler Jacks	Nf2 +/-; p53 +/-	McClatchey AI et al. 1998. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes & Development 12(8):1121-1133.	tjacks@mit.edu