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Vision

To eradicate breast cancer by funding innovative, high-impact research through a partnership of scientists and consumers

Total Appropriations

$2.36 billion in FY92-09

FY10 Appropriations:

$150 million

Publications of Interest

  • Smith GL, Shih YT, Xu Y, et al. 2009. Racial disparities in treatment for early invasive breast cancer: a national Medicare study of radiotherapy after conservative surgery. Cancer 116:734-741.


  • Sugahara KN, Teesalu T, Karmali PP, et al. 2010. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328:1031-1035.


  • Valastyan S, Reinhardt F, Benaich N, et al. 2009. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137:1032-1046.


  • La Merrill M, Harper R, Birnbaum LS, et al. 2010. Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice. Environ Health Perspect 2010. 118:596-601.


  • Silvera D, Arju R, Darvishian F, et al. 2009. Essential role for eIF4GI overexpression in inflammatory breast cancer pathogenesis. Nature Cell Biol 11:903-910.


  • Frieboes HB, Edgerton ME, Fruehauf JP, et al. 2009. Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res 69(10):4484-4492.


  • Kim MY, Oskarsson T, Acharyya S, et al. 2009. Tumor self-seeding by circulating cancer cells. Cell 139:1315-1326.


  • Ibarra C, Wilke L, Yee L, et al. 2009. Random periareolar fine needle aspiration is highly reproducible in a cooperative multi-institutional trial. Cancer Epi Biomarkers Prev 18:1379-1384.


  • Palmieri D, Lockman PR, Thomas F, et al. 2009. Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer. Clin Cancer Res 15:6148-6157.


  • McCarty KM, Santella RM, Steck SE, et al. 2009. PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk. Environ Health Perspect 117(4):552-558.


  • Shen J, Ambrosone CB, and Zhao H. 2009. Novel genetic variants in microRNA genes and familial breast cancer. Int J Cancer 124(5):1178-1782.


  • Korpal M, Yan J, Lu X, et al. 2009. Imaging TGF-signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med 15(8):960-966.


  • Espina V, Mariani B, Gallager R, et al. 2010. Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival. PLoSONE 5:4-e10240.


  • Matrone MA, Whipple RA, Thompson K, et al. 2010. Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells. Oncogene 29(22):3217-3227.
Disease Background: Breast cancer is the most commonly diagnosed cancer in women, accounting for 28% of all cancers diagnosed in women this year. One of every eight women will develop breast cancer in her lifetime.

2010 Projections:
  • An estimated 207,090 women in the United States will receive a diagnosis of invasive breast cancer.
  • An estimated 54,010 women will be diagnosed with in situ breast cancer.
  • An estimated 39,840 women will die of breast cancer.
  • Although male breast cancer is rare, an estimated 1,970 men will be diagnosed with breast cancer and approximately 390 men will die of the disease.

Overview of the Program: Since its inception in 1992, the Breast Cancer Research Program (BCRP) has funded research targeted toward the program's vision to eradicate breast cancer. The DoD BCRP has developed a multidisciplinary research portfolio that encompasses a wide spectrum of prevention, detection, diagnosis, and treatment research projects. The BCRP specifically avoids duplication of research funded by other federal agencies. Research awards are made using a two-tier review process composed of peer and programmatic review. An important element of the BCRP's vision is to foster partnerships between scientists and consumers, who are integral participants at both levels of review. Peer review evaluates the scientific merit of the research proposals, and programmatic review determines the relevance of proposals to the BCRP vision and goals. The Integration Panel, comprised of scientists and consumers, makes final funding recommendations and provides guidance on the BCRP's investment strategies.

The program's initial success encouraged Congress to appropriate additional funds to the BCRP in subsequent years, totaling over $2.5 billion through FY10. From FY92-FY09, a total of 42,118 proposals have been received, and 5,915 awards have been funded or recommended for funding. An additional 275 awards are anticipated for FY10. All funds for FY10 awards will be obligated by September 30, 2011.

Details on each funded award are located on the CDMRP website under Search Awards. Recent highlighted research is located on the CDMRP website under Research Highlights and in the Program Booklet.

For more information, please contact cdmrpwebmaster@cdmrp.org.