DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

NEWS RELEASE

Released: July 2, 2009

Department of Defense Peer Reviewed Orthopaedic Research Program
Funding for Fiscal Year 2009 (FY09)

Fiscal Year 2009 (FY09) congressional appropriations (Public Law 110-329 and 111-32), provide $61 million (M) and $51M, respectively, for a total appropriation of $112M to the Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP)to support innovative, high-impact, clinically relevant research to advance treatment and rapid rehabilitation from musculoskeletal injuries sustained during military combat or combat-related activities. This program is administered by the US Army Medical Research and Materiel Command (USAMRMC) through the Office of Congressionally Directed Medical Research Programs (CDMRP).

FY09 PRORP Program Announcements and Application Instructions & General Information for the following award mechanisms are anticipated to be posted on Grants.gov in July 2009. Additional award mechanisms for the FY09 PRORP will be announced in August 2009.

Award Mechanism Eligibility Key Mechanism Elements Funding
Clinical Trial Award Assistant Professor or above (or equivalent)
  • Requires preproposal; preproposals will be screened and Principal Investigators (PIs) invited to submit full proposals
  • Provides for rapid execution of novel, patient-oriented research in Phase 0, Phase I, Phase II, Phase III or combination clinical trials that will have a significant impact on acute or definitive care of military combat-related orthopaedic injuries
  • Research focus areas include: enhancement of the tissue environment for healing; prevention of complications; restoration of joint function; and treatment of orthopaedic injuries (and sequelae) of the spine not related to spinal cord injury
  • Preliminary data are required
  • Clinical trials are expected to be initiated within 12 months of the award date
  • IND/IDE approval should be in place by June 30, 2010
  • Career Development Associate Option: Additional funds may be requested to support the career development of a junior investigator located at a military treatment facility
  • Maximum funding of $2.5M for direct costs (plus indirect costs)
  • Period of performance 4 years
  • Career Development Associate Option: Maximum funding of $2.725M for direct costs (plus indirect costs)
  • Anticipate 8 awards
Hypothesis Development Award Investigators at all academic levels (or equivalent)
  • Requires letter of intent
  • Funds the initial exploration of innovative, untested, potentially groundbreaking concepts in all areas of orthopaedic research relevant to treatment and rehabilitation from military combat-related injuries
  • Preliminary data are not expected
  • Blinded review
  • Funds to directly support clinical trials are excluded
  • Maximum funding of $100K for direct costs (plus indirect costs)
  • Period of performance not to exceed 18 months
  • Anticipate 14 awards
Idea Development Award Investigators at all academic levels (or equivalent)
  • Requires preproposal; preproposals will be screened and PIs invited to submit full proposals
  • Supports conceptually innovative, high-impact research from all areas of basic, translational, and clinical research as they relate to the research focus areas
  • Research focus areas include: enhancement of the tissue environment for healing; prevention of complications; maintenance/enhancement of long-term socket performance/fit; solution of critical issues in osseointegration
  • Innovation is the most important review criterion
  • Preliminary data are not required
  • Funds to directly support clinical trials are excluded
  • Maximum funding of $400K for direct costs (plus indirect costs)
  • Period of performance not to exceed 3 years
  • Anticipate 6 awards
Technology Development Award All independent investigators
  • Requires preproposal; preproposals will be screened and PIs invited to submit full proposals
  • Provides funding for improved technologies and resources to advance the field of research focused on military combat-relevant orthopaedic injury and rehabilitative medicine
  • Research focus areas include: development of in vivo translational models for the acute injury environment and for restoration of joint function; maintenance/ enhancement of long-term socket performance/fit
  • Preliminary data are required
  • Funds to directly support clinical trials are excluded
  • Maximum funding of $2M for direct costs (plus indirect costs)
  • Period of performance not to exceed 4 years
  • Anticipate 3 awards
Translational Research Partnership Award All independent investigators
  • Requires preproposal; preproposals will be screened and PIs invited to submit full proposals
  • Multiple awards made per project
  • Supports the development of multi-institutional, multidisciplinary translational research partnerships between clinicians and laboratory scientists to accelerate the movement of promising research ideas into clinical applications in a manner that would be less readily achievable through separate efforts
  • Research focus areas include: restoration of joint function; orthopaedic injuries (and sequelae) of the spine not related to spinal cord injury; acceleration of healing; development of a functional innervated muscle for repair of soft tissue injury; solution of critical issues in osseointegration
  • Preliminary data is required.
  • Funds to directly support clinical trials are excluded
  • Maximum funding of $750K for direct costs (plus indirect costs)
  • Period of performance not to exceed 3 years
  • Anticipate 3 awards

Information in this pre-announcement is being provided to allow investigators time to plan and develop applications. The government reserves the right to make changes to the award mechanisms offered and the mechanism elements if necessary. All applications must conform to the final Program Announcements and Application Instructions & General Information that will be available for electronic downloading from the Grants.gov website in July and August 2009. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all USAMRMC funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

A pre-application (letter of intent or preproposal) is required for all award mechanisms and must be submitted through the CDMRP eReceipt website (https://cdmrp.org) prior to application submission. Applications must be submitted through the federal government's single-entry portal, Grants.gov. Requests for email notification of the release of Program Announcements may be sent to help@cdmrp.org. For more information about the PRORP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

Point of Contact:


Last updated Monday, January 25, 2016