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FY13 PROGRAM UPDATE

Released: January 30, 2013

DEPARTMENT OF DEFENSE NEUROFIBROMATOSIS RESEARCH PROGRAM
FISCAL YEAR 2013 STRATEGIC PLAN

The Department of Defense Neurofibromatosis Research Program (NFRP) is administered by the US Army Medical Research and Materiel Command through the Office of the Congressionally Directed Medical Research Programs (CDMRP).

To allow investigators time to plan and develop applications, NFRP is providing its strategic plan for award mechanisms to be offered in 2013 should funding become available. Congressional funds for the FY13 NFRP have not yet been appropriated, and this document is not to be construed as an obligation by the government; there is no guarantee of funding for these planned mechanisms.

Areas of Emphasis: The FY13 NFRP encourages research projects applications that specifically address the critical needs of the NF community in the following areas of emphasis:

  • Cognitive and social dysfunction in the setting of NF;
  • Drug discovery for the treatment of NF;
  • Heterogeneity of neurofibromas and other NF-related tumors using genomics, epigenetics, systems biology, or other similar approaches;
  • Manifestations of NF post-adolescence;
  • Novel disease markers such as imaging and proteomics of NF;
  • Pain in the setting of NF.

Award Mechanism PI Eligibility Key Mechanism Elements
Clinical Trial Award Must be an independent investigator at or above the level of Assistant Professor (or equivalent)
  • Fund Phase 0, I, or II clinical trials relevant to NF and/or schwannomatosis; combinations of phases are permitted
  • Preclinical data required
  • Phase I or pilot clinical trial data required for Phase II clinical trial applications
Exploration - Hypothesis Development Award All levels of experience
  • Fund the initial exploration of innovative, untested research, and pursue serendipitous observations
  • Projects involving human subjects or human biological substances must be exempt under 32 CFR 219.101(b) or eligible for expedited review under 32 CFR 219.110 or 21 CFR 56.110
  • Preliminary data is encouraged but not required
  • Clinical trials not allowed
Investigator-Initiated Research Award Must be an independent investigator at or above the level of Assistant Professor (or equivalent)
  • Fund basic and clinically oriented research relevant to NF and/or schwannomatosis
  • Optional Feature: Applications that include either a Qualified Collaborator or Postdoctoral Fellow who meet criteria identified in the announcement may apply for a higher level of funding
  • Preliminary data required
  • Clinical trials not allowed
New Investigator Award Must be an independent investigator at or below the level of Assistant Professor (or equivalent) or an established investigator at or above the level of Assistant Professor seeking to transition into a career in NF research
  • Fund investigators in the early stages of their careers
  • Experience in NF research is allowed, but not requiredv
  • Preliminary data required
  • Clinical trials not allowed

All applications must conform to the final program announcements and general application instructions that will be available for electronic downloading from the Grants.gov website upon official announcement of funding opportunity release. Submission deadlines will not be available until the program announcements are released. Requests for email notification of the program announcements release may be sent to help@cdmrp.org. For more information about the NFRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

Point of Contact:

CDMRP Public Affairs
301-619-9783
CDMRP.PublicAffairs@amedd.army.mil