Released: June 20, 2014

Defense Health Program
Clinical and Rehabilitative Medicine Research Program
Reconstructive Transplantation Research
Funding Opportunity for Fiscal Year 2014

The Fiscal year 2014 (FY14) Defense Appropriations Act provides $15 million (M) to the Department of Defense Reconstructive Transplantation Research Program (RTR) to support the science and execution of complex limb and face transplants. This program is administered by the US Army Medical Research and Materiel Command, the Clinical and Rehabilitative Medicine Research Program (CRMRP), through the Office of Congressionally Directed Medical Research Programs (CDMRP) and the Tissue Injury and Regenerative Medicine Project Management Office.

The CRMRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. An FY14 DMRDP-CRMRP-RTR Program Announcement and General Application Instructions for the following award mechanism are anticipated to be posted on the website in July 2014. Pre-application and application deadlines will be available when the Program Announcement is released. This pre-announcement should not be construed as an obligation by the government.

Focus areas:
The CRMRP challenges the scientific community to design innovative research that will foster new directions for and address neglected issues in the field of reconstructive transplantation research (RTR), specifically vascular composite allotransplantation (VCA)-focused research. VCA refers to the transplantation of multiple tissues such as muscle, bone, nerve and skin, as a functional unit (e.g., a hand, or face) from a deceased donor to a recipient with a severe injury. Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the Department of Veterans Affairs (VA), and other Federal Government agencies are highly encouraged. Though the RTR Award mechanism supports groundbreaking research, all projects must demonstrate solid scientific rationale with military-relevant utility. The CRMRP encourages research projects that specifically address the critical needs of the RTR program in specific Focus Areas including:

Immune Rejection
    Understanding mechanisms of immune rejection
    Immunomodulation approaches and mechanisms, e.g., tolerance induction, chimerism
    Optimizing immunosuppressive drug regimens
Graft Surveillance-Clinical Monitoring
    Immune profiling, e.g., gene expression, graft rejection markers, cytokine screens
Standardization of Processes and Protocol
    Collaboration in clinical protocol standardization, which may include endpoint selection, assay selection and functional outcomes measures
    Techniques for tracking long-term outcomes
    Standardization of procedures for pathology

Award Mechanism Eligibility Key Mechanism Elements Funding
Reconstructive Transplantation Research Principal Investigator: Independent investigators at all academic levels (or equivalent) and from industry
  • Pre Clinical Studies: projects that focus on preclinical research that addresses at least one RTR Award Focus Areas, or identifies a unique focus area applicable to RTR. These studies may utilize animal models and/or human cell lines or samples
  • Clinical Research/ Clinical Trials: the clinical research/ clinical trial must be more than 50% of the proposed work and must be initiated by the second year of the project.
  • Pre Clinical studies: Maximum funding of $750,000 plus indirect costs.
  • Clinical Research/ Clinical Trials: Maximum funding of $2,000,000 plus indirect costs.
  • Period of performance not to exceed 4 years.
  • Indirect costs may be proposed in accordance with the institution's rate agreement.

All applications must conform to the final Program Announcement and General Application Instructions that will be available for electronic downloading from the website. The application package containing the required forms for this award mechanism will also be found on A listing of all USAMRMC funding opportunities can be obtained on the website by performing a basic search using CFDA Number 12.420.

A pre-application is required and must be submitted through the CDMRP electronic Biomedical Research Application Portal (eBRAP) ( prior to the pre-application deadline. Applications must be submitted through the federal government's single-entry portal, Submission deadlines are not available until the Program Announcement is released. Requests for email notification of the Program Announcement release may be sent to Email notifications of funding opportunities are sent as a courtesy and should not be used as a sole source of notification; applicants should monitor for official postings of funding opportunities.

For more information about the CRMRP-RTR or other CDMRP-administered programs, please visit the CDMRP website (

Point of Contact:

CDMRP Public Affairs