DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

NEWS RELEASE

Released: May 28, 2015

Department of Defense Military Burn Research Program
Funding Opportunities for Fiscal Year 2015 (FY15)

The FY15 Defense Appropriations Act provides $8 million (M) to the Department of Defense Military Burn Research Program (MBRP) to support high-impact burn injuries research. Applications to the Fiscal Year 2015 (FY15) Military Burn Research Program (MBRP) are being solicited by the U.S. Army Medical Research Acquisition Activity (USAMRAA). The executing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).

The MBRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. FY15 MBRP Program Announcement and General Application Instructions for the following award mechanism are anticipated to be posted on the Grants.gov website in late June or early July 2015. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the government.

Topic Areas: The MBRP encourages applications that specifically address the critical needs of the burn research community in one of the FY15 Topic Areas. The MBRP will solicit research applications for the following FY15 Topics Areas:

  1. Fluid Resuscitation Studies (Human)
    a) Through multicenter prospective observational studies (retrospective or prospective), demonstrate the impact of various fluid resuscitation rates and techniques, as well as various adjunctive therapies (high-dose/low-dose vitamin C, albumin timing, etc.) on clinically relevant outcomes during acute burn resuscitation.
  2. Organ Failure Studies (Human)
    a) Through clinical studies, provide insight into the epidemiology, prevention, early detection, and/or treatment of single or multiple organ failure in the burn/trauma patient.
    b) Provide a systematic approach to define sepsis in burns and the impact of sepsis-related outcomes through the identification and establishment of best practice while evaluating longitudinal adherence to established standards.
  3. Wound Healing (Animal/Human)
    a) Determine specific physiological factors that result in delayed wound healing, such as shock, edema, immune system dysregulation, etc.
    b) Evaluate or develop strategies (dressing, topicals, biologics, etc.) that optimize healing of acute burn wounds.
    c) Identify diagnostic predictors (biomarkers, imaging techniques, physical wound changes, etc.) that can be used to indicate failure of wound healing.
  4. Prolonged Field Care and Delayed Evacuation (Animal/Human)
    a) Determine the clinical impact of delayed definitive therapy and/or resuscitation in a burn injury animal model.
    b) Through observational or retrospective studies, describe the impact of delayed care at intermediary facilities, prolonged time to initial treatment, and/or extended transport times on short- and long-term patient outcomes (days on ventilator, development of organ complications, compartment syndrome, limb loss, infection, etc.).
  5. Short- and Long-Term Functional Outcomes
    a) Through retrospective or prospective studies, identify issues that effect, as well as strategies to improve, physical and/or mental functional outcomes (both short- and long-term). Examples of items to include are social reintegration, duration in intensive care units, range of motion in the affected limb(s), number and types of procedures performed, the use of coping strategies/interventions to mitigate post-traumatic stress disorder, and other strategies that help improve patient outcomes after discharge.

Award Mechanism PI Eligibility Key Mechanism Elements Funding
Burn Injuries Research Award Independent investigators at all academic levels (or equivalent)
  • Supports innovative approaches to accelerate the translation of advances in knowledge into new standards of care for the treatment of the injured Warfighter who sustains burn injuries.
  • Must specifically address one of the FY15 Topic Areas
  • Research that is already supported by preliminary data and has the potential to make significant advancements toward clinical translation is required for Funding Level 1.
  • Advanced translational studies that have the potential for near-term clinical investigation are required for Funding Level 2.
  • Clinical trials are allowed.
  • Preproposal is required; application submission is by invitation only
    Funding Level 1
  • The maximum period of performance is 3 years.
  • The maximum allowable funding for the entire period of performance is $750,000 in total costs.
    Funding Level 2
  • The maximum period of performance is 4 years.
  • The maximum allowable funding for the entire period of performance is $2 million in total costs.

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all USAMRMC funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

Applications must be submitted through the federal government's single-entry portal, Grants.gov. Submission deadlines are not available until the Program Announcements are released. Requests for email notification of the Program Announcements release may be sent to help@eBRAP.org. Email notifications of funding opportunities are sent as a courtesy and should not be used as a sole source of notification; applicants should monitor Grants.gov for official postings of funding opportunities.

For more information about the MBRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil