DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Genomic Approaches for Detection and Treatment of Breast Cancer

Principal Investigator: ELLEDGE, STEPHEN J
Institution Receiving Award: BRIGHAM AND WOMEN'S HOSPITAL, INC.
Program: BCRP
Proposal Number: BC032225
Award Number: W81XWH-04-1-0197
Funding Mechanism: Innovator Award
Partnering Awards:
Award Amount: $4,999,931.00


PUBLIC ABSTRACT

This project revolves around two general approaches to attack breast cancer. The two key aspects of successful cancer treatment beyond prevention are early detection and specific killing of tumor cells without killing normal tissues. We propose to approach both of these aspects using novel methods. For early detection, we plan to explore whether the immune system can act as an early warning system to indicate the presence of tumorigenic activity. If so, this could be employed as an early cancer diagnostic method. The second approach is to take advantage of new emerging technologies to kill cancer cells with defined lesions. For example, many breast cancers have lost the potent tumor suppressor p53. If we could use genetics in mammalian cells to search for genes which when turned off will kill tumor cells lacking p53, this would be an anticancer drug target. We propose to search for such genes using genetic screens.