DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

Vision - A time when post-traumatic epilepsy can be prevented or optimally managed

Epilepsy Program Cover Image
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Epilepsy Research Program Cover Image
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ERP Post-Traumatic Epilepsy Brief
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ERP Post-Traumatic Epilepsy Brief
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The ERP was initiated in 2015 to develop an understanding of the magnitude of post-traumatic epilepsy (PTE) within the military and to expand research into the basic mechanisms by which traumatic brain injury (TBI) produces epilepsy. To this end, and to satisfy the ERP's Mission and Vision, the ERP has identified the following research Focus Areas for FY21:

  • Innovative Research: Tools intended to better inform or improve upon how PTE research can be performed:
    • Hardware and/or software platforms that will improve seizure detection, characterization, or diagnosis
    • Bioinformatics strategies, to include machine learning, that will improve access, annotation curation and visualization of large and novel datasets from single or multiple sources
    • Development of new models or better characterization of existing etiologically relevant models for PTE
    • Characterization of the circuits involved in PTE
    • Validate targets of post-traumatic epileptogenesis or established PTE
  • Markers and Mechanisms: Identifying markers or mechanisms via preclinical models that address PTE, which may include the following:
    • Biomarkers (acute and chronic)
    • Treatment
    • Prevention
    • Comorbidity
  • Epidemiology: Epidemiological characterization of PTE following TBI, which may include the following:
    • Risk factors such as demographics, genetics, anatomy, pathology, or type of injury
    • Outcomes including latency to epilepsy, comorbidities, and mortality
    • Pre-existing conditions including psychological and psychiatric risk factors
    • Treatment and healthcare outcomes research
    • Differentiation of PTE and psychogenic non-epileptic seizures (PNES)
  • Longitudinal Studies: Studies of the evolution of PTE, which may include the following:
    • Seizure frequency and semiology
    • Demographics, genetics, anatomy, pathology, or type of injury
    • Comorbidities (e.g., depression, functional deficits, sleep disorders, major illness)
    • Latency between type of injury and PTE
    • Mortality
    • Treatment and healthcare outcomes research
  • Quality of Life: Understanding and improving the quality of life of individuals with PTE, their families, and their caregivers, which may include the following:
    • Psychosocial factors
    • Neuropsychological dysfunction (cognition and memory)
    • Behavioral health (anxiety, depression, post-traumatic stress disorder [PTSD], impulsivity)
    • Wellness
    • Reducing stigma
    • Activities of Daily Living (ADLs)
    • Reducing healthcare disparities (adjunct programs, support groups, access to care)
    • Sleep disorders
    • Medication side-effects

Congressional Appropriations

Congressional Appropriations

  • $49.5 million
    FY15-FY20
  • $12 million
    FY21

...

Funding
Summary


Related Videos

Dr. Karen Parko

Department of Veterans Affairs, Epilepsy Centers of Excellence
Resolving the Connection Between TBIs and Epilepsy

Jay Hennessy

Epilepsy Foundation of Florida
A Consumer’s Perspective: Two Minutes Could Change Your Life

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Vision

A time when post-traumatic epilepsy can be prevented or optimally managed

Mission

To understand the mechanisms of post-traumatic epilepsy and associated comorbidities to improve quality of life, especially in Service members, Veterans, and caregivers

Last updated Friday, July 30, 2021