Current Research Highlights/News & Results

Alcohol and Substance Use Disorders:

• N-acetylcysteine Treatment of Alcohol Use Disorder in Veterans with Traumatic Brain Injury

Amyotrophic Lateral Sclerosis:

• In Vivo Imaging and Novel Therapeutic Approaches in ALS
• A Challenge Best Tackled Together – Bridging the ALS Therapeutic Gap with Industry Partners
• Novel Metabolic Mechanism Implicated in an Early-Onset Form of Amyotrophic Lateral Sclerosis
• Novel ALS therapeutic intervention shows promise in preclinical trials
• ALS “Disease in a Dish” Creates Opportunities for Advanced Motor Neuron and Therapeutic Drug Screening
• Amyotrophic Lateral Sclerosis (ALS) Treatment, AT-1501, Enters Clinical Trial
• Treatment Spotlight: Q&A with ALSRP Investigator Dr. Sytske Moolenaar
• Targeting miR-155 in Peripheral Monocytes for the Treatment of ALS
• The Petrucelli group creates mice that model the most common cause of ALS and FTD
• Development of Copper ATSM as a Therapeutic for SOD-Familial and Sporadic ALS

Autism:

• Flame Retardant Exposure During Early Development and Autism Spectrum Disorder
• Using Propranolol to Treat the Core Symptoms of Autism Spectrum Disorder
• Prenatal Polyunsaturated Fatty Acid Levels and Risk of Autism Spectrum Disorders
• A Clinical Trial of a Commercially Available Intervention in Pediatric Patients with Autism Spectrum Disorder and Moderate Language Delays
• The Development of Novel Drugs to Treat the Core Symptoms of ASD
• Evidence-Based Social-Emotional Therapy Using Augmented and Virtual Reality on Google Glass to Improve Employability and Job Skills in Adults with Autism
• Facilitating the Transition to Employment for Young Adult Military Dependents with Autism Spectrum Disorder
• Cognitive Enhancement Therapy: A Promising Approach for Adults with Autism Spectrum Disorder
• Understanding the Consequences of Aging in Autism Spectrum Disorder
• Maternal Brain-Reactive Antibodies and Autism Spectrum Disorder
• Altered Placental Tryptophan Metabolism: A Crucial Molecular Pathway for the Fetal Programming of Neurodevelopmental Disorders
• Risk Factors, Comorbid Conditions, and Epidemiology of Children with Autism in Military Families

Bone Marrow Failure:

• Therapeutic Targeting of Spliceosomal-Mutant Acquired Bone Marrow Failure Disorders
• Replicating the Patient-Specific Bone Marrow Failure Disease in Order to Identify Therapeutic Response
• A Method for Rescuing Hematopoietic Stem Cell Functions in Fanconi Anemia
• A Novel Therapy for Targeting Acquired Bone Marrow Failure Diseases
• The Role of U2AF1 Mutations in the Pathogenesis of Myelodysplastic Syndromes
• Signaling Pathways in the Pathogenesis of Diamond Blackfan Anemia
• Translational Control in Bone Marrow Failure

Breast Cancer:

• Investigating Estrogen Receptor Mutations in Breast Cancer to Guide New Therapeutic Strategies
• Targeting Prolyl Peptidases in Triple-Negative Breast Cancer
• Identifying a Gene Panel to Predict Risk of Recurrence in Patients with Basal-Like Breast Cancer
• Targeting Senescence May Prevent Chemotherapy-Induced Bone Loss in Breast Cancer Patients
• Stromal Lysyl Hydroxylase 2, a Novel Biomarker for Breast Cancer Patient Prognosis
• Cluster of Differentiation 73 (CD73) Blockade Promotes Dendritic Cell Infiltration of Primary Tumors and Activation of Antitumor Immune Responses
• Mitochondria-Targeted Copper-Depleting Nanoparticle Inhibits Triple-Negative Breast Cancer Progression in Mice
• Metabolomic Targeting of Heterogeneous Breast Cancer for Personalized Therapy Development
• Ruxolitinib for the Prevention of Breast Cancer
• Fasting-Mimicking Diet Induces Breast Cancer Regression Through Enhanced Effectiveness of Hormone Therapy
• Characterization of Clustered Circulating Tumor Cells to Eliminate Breast Cancer Metastasis
• New Diagnostic and Therapeutic Approaches to Eradicating Recurrent Breast Cancer
• De-Escalating Treatment in HER2+ Breast Cancer: Establishing Effective and Less Toxic Therapy Based on Predictive Biomarkers
• Podcast Discusses the DoD Breast Cancer Research Program and Metastatic Breast Cancer Research
• Lab-on-Chip (LOC) Platform for Assessment of Extracellular Matrix (ECM) Stiffness
• Targeting miR551b to Prevent Tumor Formation and Metastasis of Triple-Negative Breast Cancer (TNBC)
• Death Effector Domain-Containing Protein (DEDD) Vulnerability to Cell Cycle Inhibition in Triple-Negative Breast Cancer (TNBC)
• Enhancing the Cytotoxicity of T-DM1 to Treat HER2+ Breast Cancer
• Connecting Blood and Intratumoral Treg Cell Activity in Predicting Future Relapse in Breast Cancer
• Era of Hope Scholars – Making Breakthroughs in Preventing Metastasis
• 2019 BCRP Landscape Video
• Blocking CXCR4 Reduces Tumor Fibrosis and Sensitizes Metastatic Breast Cancer to Immunotherapy
• Neutrophil Extracellular Traps Produced During Inflammation Awaken Dormant Cancer Cells
• Reprogramming the Pro-Tumorigenic Immune Microenvironment to Anti-Tumorigenic in Breast Cancer
• RANKL/RANK Control BRCA1 Mutation-Driven Mammary Tumors
• Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy
• The Link Between Chromosomal Instability and Metastatic Progression in Triple-Negative Breast Cancer
• Imaging Agent, Flurodeoxyglucose (¹⁸F-FDG), Transforms Chemotherapeutics into Phototherapy for Precise Treatment of Metastatic Breast Cancer
• Atf3 in Non-Cancer Host Cells is Linked to Chemotherapy-Enhanced Metastasis in Breast Cancer
• Her2 and TrkB as Dual Therapy Targets for Her2+ Breast Cancer Brain Metastases
• Targeting the Cytoskeletal Physics of Circulating Breast Tumor Cells to Reduce Metastasis
• Uncovering a New Pathway to Target and Treat Breast Cancer Metastasis
• The Multifunctional Transcription Factor, TRIM25, Drives Breast Cancer Metastasis
• RON kinase: A Target for Treatment of Cancer-Induced Bone Destruction and Osteoporosis
• CDK4/6 Inhibition Triggers Antitumor Immunity
• The Flare Behind Tumor Imaging to Rapidly Measure Breast Cancer Response to Therapy
• Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis
• Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer
• Breast Cancer Geneticist Awarded 2017 Breakthrough Prize
• Prediction of Metastasis Using Second Harmonic Generation

Defense Medical Research and Development:

• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• THE PAP SMEAR CHALLENGE: COMPARING CLINICAL PERFORMANCE OF A NOVEL “MOLECULAR PAP” BASED ON NEXT-GENERATION SEQUENCING TO TRADITIONAL CERVICAL CANCER SCREENING
• Remote Anger and Stress Management (M-SAT)
• Adapting SmartPhones for Ocular Diagnosis
• Closed Loop Total Intravenous Anesthesia (TIVA): The Battlefield Anesthetic of the Future
• Understanding the Protective Effects of Cellular Prion Protein (PrP^C) and Cell Death Protease Inhibition for Treating TBI
• Military Suicide Research Consortium: Recent Accomplishments from Cutting-Edge Studies
• Smart Oxygen Monitors to Diagnose and Treat Cardiopulmonary Injuries
• Identification and Validation of Novel Therapeutic Targets for Traumatic Brain Injury
• Army Medicine Opens the Door for Vision Prosthetic Prototypes
• Novel Detection of Traumatic Brain Injuries
• Characterization of a Model of Blast-induced Mild Traumatic Brain Injury

• Military Infectious Diseases Research Program (JPC-2)

  • Novel Antimicrobial Peptides as Topical Anti-Infectives Against Combat-Related Bacterial and Fungal Wound Infections
  • A Novel, Broad Spectrum Anti-Infective that Provides Novel Regenerative Properties in Skin
  • Development of Novel Kinocidin-Based Anti-Infective Therapeutics
  • Preclinical Development of an Antimicrobial Nanoemulsion to Investigational New Drug for Multidrug-Resistant Wound Infections
  • Fighting the Insect War: Containing Vector-Borne Disease and Strengthening Our Military Overseas
  • Rapid Diagnostics for Multidrug Resistant Organisms in Combat-Related Infection
  • Development of a Novel, Antimicrobial Skin Substitute for Burn Patients
  • Fighting Bacteria with Bacteria: Controlling Wound Infections with Predatory Bacteria
  • Next Generation Antimicrobial Wound Dressings to Reduce Infection and Promote Wound Healing

• Military Operational Medicine Research Program (JPC-5)

  • Healing from Traumatic Events by Targeting Feelings of Guilt
  • Blue Light Therapy: A Promising Supplemental Approach to Lessen PTSD Symptom Severity
  • Written Exposure Therapy: An Efficient and Effective Treatment for PTSD
  • PHQ and SCS Working Together to Improve Suicide Risk Detection
  • Wingman-Connect Program: An Impactful Collaboration between Academia and the Air Force
  • ADAPT and Marriage Checkup Together are Strengthening Military Families
  • Lethal Means Counseling and Distribution of Cable Locks Increase Safe Firearm Storage among Military Personnel
  • Evaluating Sex Differences as a Predictor of Risk for Opioid Use Disorder
  • Decreasing Aggression in Veterans with PTSD
  • Using Virtual Reality as a Training Tool to Enhance the Proficiency of Behavioral Health Providers
  • Targeted Strategies to Accelerate Evidence-Based Psychotherapies Implementation in Military Settings
  • Finding Love Again After PTSD: Intensive Group Couple Therapy for PTSD
  • Identifying Biomarkers that Distinguish Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury Using Advanced Magnetic Resonance Spectroscopy
  • Advances in Understanding Suicidal Ideation and Behavior
  • What’s in Your Uniform? An Investigation of Permethrin-Treated Army Combat Clothing
  • Effectiveness and Patient Acceptability of Stellate Ganglion Block for Treatment of Posttraumatic Stress Disorder Symptoms among Active Duty Military Members
  • Designing Predictive Models for Musculoskeletal Injury and Injury Reoccurrence After Returning to Full Duty Following an Injury
  • Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Cognitive Processing Therapy (CPT) Shows Promise for Reducing Symptoms of Combat-Related PTSD in Veterans
  • Researchers Develop Operationally Specific Auditory Tests to Assess Fit-for-Duty Hearing Performance in Service Members
  • Military Suicide Research Consortium Hosts Dissemination Science Institute to Address the Need for Effective Health Communication Strategies
  • 2018 San Antonio Combat PTSD Conference Draws Record Attendance, Delivers a Powerful Program
  • Open house event celebrates the partnership between STRONG STAR and CRDAMC, a key collaboration in furthering the treatment of PTSD
  • Toward a Gold Standard for Suicide Risk Assessment for Military Personnel
  • Texting: A Brief Intervention to Prevent Suicidal Ideation and Behavior
  • Development and Evaluation of Veteran Supportive Supervisor Training (VSST): Improving Transition for Veterans in the Workplace
  • Improvement and Extension of Auditory Hazard Models

• Combat Casualty Care Research Program (JPC-6)

  • Human Neural Stem Cells, a New Approach to Restorative Therapy for Severe Traumatic Brain Injury
  • Optimized Liposomal Dexamethasone Therapy Improves Functional Outcome of Post-Traumatic Skeletal Muscle and Neuromuscular Junction
  • CN-105, a Prophylactic Neuroprotectant Against Traumatic Brain Injury
  • Novel Prosurvival Strategies Enhance Prolonged Field Care

Duchenne Muscular Dystrophy

• New Potential Antibody Treatment for Duchenne Muscular Dystrophy
• Steps Forward in Treating Duchenne Muscular Dystrophy with Gene Repair Therapy
• AAV Vectors, A Step Toward Duchenne Muscular Dystrophy Clinical Trials
• Preclinical Testing of a Novel Method to Block TGFbeta Family Proteins in DMD

Epilepsy

• Re-Imagining Epilepsy Treatments – A Cocktail of Novel Small Molecules Shows Promise for Blocking Post-Traumatic Epilepsy
• Large Animal Models of TBI May Reveal the Mechanisms Behind Post-Traumatic Epilepsy
• The Epidemiology of Epilepsy and Traumatic Brain Injury: Severity, Mechanism, and Outcomes
• Hope for Repurposing an Anti-Diabetic Drug as a Potential Therapy in Pediatric TBI
• Dr. Karen Parko - Resolving the Connection Between TBIs and Epilepsy

Gulf War Illness:

• Boston University Tackles Gulf War Illness Through Collaboration and Community Resources
• Life Sciences Special Issue Focuses on Gulf War Illness Research
• The Unwavering Mission of the GWIRP Thirty Years after the Persian Gulf War
• Misconceptions about GWI and the Impact of Provider Attitudes: Assessing and Addressing Problems
• CNS autoantibodies lead to a differential diagnostic test for Gulf War Illness
• Joint VA/DoD Gulf War Illness State of the Science Conference Draws Hundreds of Researchers and Veterans
• Gulf War Illness State of the Science Conference
• GWIRP-funded project expands exciting gut biome finding for Gulf War Illness
• Seeking Solutions: Veteran Learns about Gulf War Illness — TV series brings resources into view
• A Prospective Open-Label Clinical Trial of Methylphenidate plus a GWI-Specific Nutrient Formula in Patients with Gulf War Illness and Concentration Disturbances
• GWI Common Data Elements Initiative
• The Gulf War Illness Clinical Trials and Interventions Consortium and the Boston Biorepository, Recruitment, and Integrative Network for GWI
• Alabama initiative for Veteran-based research

Hearing Restoration:

• HRRP-funded investigators develop miniature imaging probe to visualize cellular pathology in the inner ear
• Addressing Both Immediate Needs and Long-Term Consequences
• Addressing Research Gaps for Our Veterans
• Confronting the Challenges of Hearing Loss: A Veteran's Perspective
• Advancing Effective Hearing Restoration Therapies

Joint Warfighter Medical:

• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Enhancing Healthcare Through Interoperability
• A New Product for the Treatment of Post-Traumatic Osteoarthritis
• Development of BIO 301 to Prevent Acute Radiation Syndrome and Mitigate the Delayed Effects of Acute Radiation Exposure

Kidney Cancer:

• The Academy of Kidney Cancer Investigators – Getting to Know Class 1 and 2
• Therapeutic Targeting of HHLA2/KIR3DL3 Axis as a Novel Immune Checkpoint Pathway in Renal Cancer
• Stromal β-catenin Activation Contributes to Abnormal Kidney Formation in Mice that Mimics Human Wilms Tumor
• Metabolic Reprogramming of Clear Cell Renal Cell Carcinoma Mediated by Tobacco Smoke
• Profilin 1 Promotes Aggressiveness of ccRCC and Provides a Potential New Therapeutic Target
• Harnessing Predictive Markers of Response to Antiangiogenic Therapy: Two Approaches to Optimizing Treatment for Metastatic Renal Carcinoma

Lung Cancer:

• Rationalizing New Therapeutic Options for Small Cell Lung Cancer Patients Through a Deeper Understanding of Disease Heterogeneity
• Exploring Modulators of TKI Therapy to Inform Better Patient Treatment for Lung Cancer
• Peripheral Blood T-Cell Dynamic Biomarkers to Identify Responders and Non-Responders in Immune Checkpoint-Based Therapy for Lung Cancer
• LCRP Awardee Receives 2021 Wachtel Cancer Research Award
• Investigating Dysbiosis of the Lung as a Biomarker for Early Lung Cancer Detection
• The Generation of Pulmonary Neuroendocrine Cells and SCLC-like Tumors from Human Embryonic Stem Cells
• Lung Cancer Research Program’s Career Development Award Expands the Talent Pool in the Field of Lung Cancer
• Targeted Inhibition of Mutant KRAS Oncogene Signaling by RAS Mimetics as a Therapeutic Approach for Lung Cancer
• Predicting Response to Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer
• MEK Inhibition Modulates TNFα Response in Lung Cancer to Enhance Therapeutic Activity
• Investigating the Role of the Lung Microbiome in Non-Small Cell Lung Cancer Tumor Initiation and Progression
• Advancing Multi-Modal Therapy for Inoperable Early Stage Lung Cancer Patients
• Is It Really Cancer? Developing a CT-Based Classifier for Indeterminate Nodules Detected by Lung Cancer Screening
• A New NSAID Shows Promise for the Prevention of Lung Cancer
• Competing for RAS – Understanding KRAS and the Effects of Its Interactions for Potential Lung Adenocarcinoma Treatment
• Antidiabetic Drugs Are a Potential Solution to Some Treatment-Resistant Tumors
• Cancer Interception: Inducing Metabolic Crisis as a Form of Treatment during Lung Carcinogenesis
• The Search for a Biomarker Reveals Mechanisms of Treatment Resistance and New Approaches to Restore Effectiveness for Targeted Therapies
• Detecting Lung Cancer in the Blood Stream: A Successful Validation of a Highly Sensitive Blood-Based Biomarker for Lung Cancer
• The Cancer Moonshot Program: APOLLO and LCRP’s Lung Cancer Biospecimen Resource Network
• The Role of the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Chemotherapy Resistance
• Fostering Collaboration Leads to Early Detection Breakthroughs in Lung Cancer
• Genetic Implications and Novel Targets for the Treatment of Non-Small Cell Lung Cancer
• Genetic Determinants of Lung Cancer Subtype: Adenocarcinoma to Small Cell Conversion
• Identification of a New Biomarker for Lung Cancer Tumor Aggression Points to Promising New Therapies
• Functional Assessment of Patient-Derived Models of Acquired Drug Resistance Identifies a New Drug Combination for EGFR Mutant Lung Cancer

Lupus

• Therapeutic Targeting of Senescent Cells in Lupus
• Systemic Lupus: Improving the Rationale for Treatment Choices in a Heterogeneous Disease
• Utility of a Functioning Report for Lupus Patients and Their Providers

Melanoma:

• Introducing the Melanoma Academy
• The Melanoma Research Program’s Renewed Focus on Rare Melanomas and a New Funding Opportunity
• Oncoprotein “RLIP” as a Novel Therapeutic Target for Melanoma Prevention and Treatment
• Fiscal Year 2021 Melanoma Research Program Academy: An Opportunity for Leadership
• Breaking the Habit: Melanoma Cells Dependence on BRAF+MEK Inhibitors
• Improving Therapy for Melanoma Brain Metastases
• Identification of the HDAC Inhibitor Quisinostat as a Possible Therapeutic for Uveal Melanoma
• Exploring Novel Ideas in Melanoma Research
• FY20 Melanoma Research Program: Filling the Gaps in Research for a Better Future
• Siah2: A Potential Biomarker to Predict Immunotherapy Treatment Outcomes in Melanoma Patients
• Role of the Inhibitory Receptor TIGIT in the Regulation of CD4+ Tregs in Patients with Advanced Melanoma
• Metabolic Remodeling of the Tumor Microenvironment to Improve the Efficacy of Immunotherapy
• Targeting Increased Polyamine Transport of Resistant Melanomas
• Central Tolerance Blockade to Augment Checkpoint Immunotherapy in Melanoma

Military Burn:

• Novel Peptide Drugs to Improve Burn Care Outcomes
• Enzymatic Debridement for Prolonged Field Care of Military Burn Wounds
• Pirfenidone-Containing Burn Wound Patch to Reduce Scarring
• Revised Goniometry for Improved Diagnosis and Physical Therapy for Burn Patients
• Omega-3 Fish Skin for Burn Wound Coverage and Advanced Healing
• COL Kevin Chung, MD, FCCM, FACP - Charting a Course Toward Resuscitation and Recovery
• Modulation of Burn Scars Through Laser Assisted Delivery of Stem Cells
• Improving the Prognosis of Soldiers with Acute Respiratory Distress Syndrome
• Clinical Therapeutic Applications of Epinephrine and Vitamin-E Supplements to Treat Burn Patients

Multiple Sclerosis:

• Physical Telerehabilitation Program for Multiple Sclerosis Patients Improves Patients’ Quality of Life
• Reduced Disease Severity Following Novel Angiotensin 1-7 Treatment in MS Mouse Model
• Imaging Measures Reflect Cognitive Changes Over Time in Multiple Sclerosis Patients
• Exercise Training, Metabolic Changes, and Symptoms in People with MS
• Exploring Remyelination in MS: Myelin, Metformin, and Mitochondria
• Acceleration of Oligodendrocyte Maturation and Functional Remyelination in an MS Model Following Flavonoid Treatment
• The Role of Protein Deimination in Restoring Visual Function in MS Patients
• Differential Association of Age and Serum Neurofilament Light Chain in MS Patients
• Online Toolkit to Assist with Self-Management of MS Symptoms
• Tap Your Feet to Track Progressive Multiple Sclerosis
• Mitochondrial Dysfunction and Disease Progression in MS
• Sensory-Motor and Cognitive-Motor Dysfunction in Multiple Sclerosis: A Mobile Brain-Body Imaging Investigation
• Using Reprogrammed Stem Cells as a Therapy for MS
• Link Between Alterations in the Gut Microbiota and Multiple Sclerosis
• Developing a Promising New Target in the Treatment of Multiple Sclerosis
• Using Advanced MRI Tools to Develop Novel Assessments of Cognition in MS Patients
• In Vivo Imaging of Cortical Inflammation and Subpial Pathology in Multiple Sclerosis by Combined PET and MRI

Neurofibromatosis:

• Genetic Risk Factors of Schwannoma Tumors
• Pharmacological Alk Inhibition Impacts Behavior and Cognition in Adult NF1 Mutant Mice
• Nf1 Mutation Drives Neuronal-Activity-Dependent Initiation of Optic Glioma
• New Investigator Award Recipients Bring New Ideas to the Neurofibromatosis Research Program for Fiscal Year 2020
• Cabozantinib for Neurofibromatosis Type 1-Related Plexiform Neurofibromas: A Phase 2 Trial
• Everolimus Therapy for NF1-Optic Gliomas in Children: A Clinical Trial
• The Pain of Neurofibromatosis
• The NFRP Supports the Future of NF Research with Several New Investigator Awards
• The NFRP Joins Efforts to Promote Open Science in NF Research
• Clinical Trials Address Quality of Life for Persons with Neurofibromatosis (NF1, NF2, and Schwannomatosis) with Resiliency Training Delivered via Live Video
• Study Finds That Bevacizumab Treatment for NF2-Related Vestibular Schwannomas Increases Reported Quality of Life in Adults and Children
• The NFRP Presents the Fiscal Year 2018 Early Investigator Research Award Recipients
• The NFRP Presents the Fiscal Year 2018 New Investigator Award Recipients
• Investigating the Role of Fibroblasts in the Tumor Microenvironment and Hippo Signaling Pathway in Neurofibromas
• Cerebellopontine Angle (CPA) Model: A Novel Tool for Investigating Immunotherapy in Neurofibromatosis Type 2 Vestibular Schwannomas
• Gaining Momentum Through Innovation and Recruitment
• Fiscal Year 2017 New Investigator Award Recipients
• Bench to Bedside - Collaborating to Develop Effective Therapies for NF
• Pathophysiology and Treatment of Muscle Weakness in NF1
• Identification of Molecular and Cellular Contributions to Neurofibroma Formation and Growth
• Fiscal Year 2016 New Investigator Award Recipients
• Potential Therapeutics for Neurofibromatosis Type 2-Associated Schwannoma Tumors
• Confronting the Challenge of Neurofibromatosis
• Identification of Novel Therapeutic Targets for NF1 Optic Pathway Glioma by Examining the Tumor as an Ecosystem
• Decreasing the Clinical Impact of Neurofibromatosis – New Clinical Trials Funded Through the Neurofibromatosis Research Program
• Deletion of Anaplastic Lymphoma Kinase improves cognitive impairments in a mouse model of Neurofibromatosis Type 1
• Study Finds that Lovastatin is Not Effective for Treating Learning or Attention Impairments in Children with NF1
• Opioid Receptor Signaling Crosstalk to Ras Protein is Mediated by Neurofibromin 1
• FY15 New Investigator Award Recipients
• Finding New Targets for Treatment of NF2-Deficient Meningiomas
• Combined mTORC1 and MEK Inhibition Leads to Regression of NF1-Mutant Cancers

Neurotoxin Exposure Treatment Parkinson's:

• The NETP Presents the Fiscal Year 2020 Early-Investigator Research Award Recipients
• Investigating the Gene-Environment Interactions Related to Parkinson’s Disease Susceptibility
• The NETP Presents the Fiscal Year 2019 Early-Investigator Research Award Recipients
• Reducing Tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson’s Disease
• Identifying an Additional Risk for Sporadic Parkinson’s Disease in the Gut Microbiome
• Dr. Angus Nairn - Proteomic Methods for Analyzing Protein in Dopaminergic Neurons
• Remembering Dr. Robert Burke: A Pioneer in Neuro-restorative Approaches to Treating Parkinson's Disease
• Dr. Andrew Singleton - Aging Whole-Genome Sequencing in Parkinson’s Disease
• Dr. Kenneth Marek - Evaluating the Natural History of Prodromal PD in the PARS Cohort
• Dr. Caroline Tanner Video - Persistent Organic Pollutants and Parkinson’s disease in Native Populations of Hawaii and Alaska
• Dr. Paul Greengard Video - New P11 Biomarker Predicts Clinical Effectiveness of Antidepressant Drugs
• Alpha-synuclein: Promising molecular test for Parkinson's disease
• PRP PI Honored at the White House as a 'Champion of Change'

Orthotics and Prosthetics Outcomes:

• Enhanced Autodiagnostic Adaptive Trainer for Myoelectric Prosthesis Users (eADAPT-MP)
• The Narrow Beam Walking Test: An Improved Clinical Balance Test for Assessing Fall Risk in Unilateral Lower Limb Prosthesis Users
• Women’s Specific Footwear with Prosthetic Feet
• A Prosthetic Foot Emulator to Optimize Prescription of Prosthetic Feet in Veterans and Service Members with Leg Amputations
• A Novel Prosthetic Foot Designed to Maximize Functional Abilities, Health Outcomes, and Quality of Life in People with Transtibial Amputation
• SpringActive Odyssey Ruggedized Ankle Prosthesis
• Improving the Control of Powered Lower Limb Prostheses

Ovarian Cancer:

• Leukemia Inhibitory Factor and Interleukin-6: Functioning in Parallel to Promote Ovarian Cancer Growth
• Exploiting the Immunometabolome to Enhance Antitumor Immunity in Ovarian Cancer
• Developing Therapeutics in Rare Subtypes of Ovarian Cancer
• Mentorship Is a Key Component for a Successful Ovarian Cancer Research Team
• Nanoparticles for Effective and Targeted Ovarian Cancer Treatment
• A microRNA Promotes Oncogenic Transformation Leading to Ovarian Cancer
• Ovarian Cancer Academy: 10 Years of Empowering Early Career Ovarian Cancer Investigators
• Combination Immunotherapies Offer New Hope for Chemotherapy-Resistant Ovarian Cancer Patients
• A Collaborative Effort has Uncovered Novel Therapies to Treat an Aggressive Form of Ovarian Cancer That is Unresponsive to Standard Treatment
• BRCA in Ovarian Cancer: Understanding the Risk and Finding New Means of Treatment
• A Multi-Institutional Approach to Understanding the Pathology of Ovarian Cancer
• A More Reliable Personalized Medicine-Based Approach to Test Ovarian Cancer Drugs
• Cyclin E1 as a Therapeutic Target for High-Grade Serous Ovarian Cancer
• The Impact of the Ovarian Cancer Academy Is Long-Lasting and Far-Reaching
• Investigation of a Novel PET Tracer to Assess PARP Inhibitor Sensitivity in Ovarian Cancer Patients
• Expert Highlights Immunotherapy Potential in Ovarian Cancer
• Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma
• Towards Understanding Ovarian Cancer Progression and Chemotherapy Resistance
• Chip-Based Magnetic Imager for Molecular Profiling of Ovarian Cancer Cells
• The Clinical Development Award: Accelerating Ovarian Cancer Research into Clinical Application
• Combination Therapy of JO-c and PEGylated Liposomal Doxorubicin/DoxilT^TM in Ovarian Cancer Patients
• Providing Hope: Increasing Long-Term Survivorship of Ovarian Cancer Patients
• Genetic Modifiers of Ovarian Cancer Risk in BRCA1 Mutation Carriers
• Optical Imaging Falloposcope for Minimally Invasive Ovarian Cancer Detection
• Ubiquitin-Mediated Protein Degradation Pathways for Ovarian Cancer Treatment
• Repurposing FDA-Approved Drug as a Potential Metastasis Inhibitor for Ovarian Cancer Treatment
• Therapeutic Strategies against Cyclin E1-Amplified Ovarian Cancers

Pancreatic Cancer:

• Early-Career Investigator Award Recipients Bring New Talent to the Pancreatic Cancer Research Program

Peer Reviewed Alzheimer's:

• Detecting and Diagnosing Different Strains of Neurodegenerative Disease
• Improving Quality of Life Through Training to Reduce Care-Resistant Behaviors
• Understanding Long-Term TBI Consequences Using Artificial Intelligence
• Alzheimer’s Effect on Financial Outcomes in the Period Prior to Clinical Diagnosis
• The Glymphatic System: A Novel Discovery for TBI and Dementia
• Collaborating on Military Risk Factors for Alzheimer’s and Other Dementias

Peer Reviewed Cancer:

• Early Career Investigators Are Developing Strategies to Improve Outcomes in Head and Neck Cancers
• Boosting Listeria Hysteria: Prime Strategies Against Cancer
• Neutro-lizing Colorectal Cancer
• Defining Mechanisms of Resistance to Immunotherapy in Head and Neck Cancer
• Oncolytic Virotherapy: Boosting the Immune Response in Brain Cancer
• Attacking Cancer with Missiles
• Multifunctional Nanofiber for Convection-Enhanced Delivery of Theranostics to Diffuse Intrinsic Pontine Glioma
• Targeting Protein Degradation in Ewing Sarcoma
• FY20 PRCRP Awards Will Investigate Novel Ways to Treat Sarcomas that Disproportionately Affect the Pediatric, Adolescent, and Young Adult Populations
• Novel Therapeutic Strategies for Overcoming Treatment Resistance in Biliary Cancers
• Mantis Shrimp Inspired Near-Infrared Endoscopy for Colorectal Cancer Surgery
• Blood Cancer Breakthrough: Recently FDA-Approved XPOVIO ^® Research Was Initially Funded by DOD
• Imaging as Predictive Biomarker for Esophageal Cancer: Offering New Hope to a Forgotten Population of Cancer Patients
• In Focus: Cancer in Children, Adolescents, and Young Adults (CCAYA)
• In Focus: Military Health and Cancer
• A Powerful New Model for Accelerating Liver Cancer Research
• Research that Considers the Whole Patient
• Investigating the Link Between Potential Cancer-Causing Pollutants in the Environment and Testicular Cancer Risk in US Air Force Servicemen
• The Fiscal Year 2020 Peer Reviewed Cancer Research Program Virtual Cancer Center: An Opportunity for Leadership
• Role of the Inhibitory Receptor TIGIT in the Regulation of CD4+ Tregs in Patients with Advanced Melanoma
• Discovering New Drug Targets in Radiation-Induced Myeloproliferative Neoplasms
• The Peer Reviewed Cancer Research Program (PRCRP) Vision Video
• Metabolic Remodeling of the Tumor Microenvironment to Improve the Efficacy of Immunotherapy
• Overcoming Tumor Immune Evasion
• IN FOCUS: Oncolytic Virotherapy in Pediatric Brain Tumors
• Turning the Heat up on Cancer: Combining Heat and Immunotherapy to Better Treat Bladder Cancer
• Targeting Increased Polyamine Transport of Resistant Melanomas
• Central Tolerance Blockade to Augment Checkpoint Immunotherapy in Melanoma
• IN FOCUS: Research in Cancers in Children, Adolescents, and Young Adults
• Neural Proteins Implicated in Pancreatic Cancer Desmoplasia
• IN FOCUS: Brain Tumor Research Funding
• IN FOCUS: BLADDER CANCER
• Exposing a Silent Killer: Dr. Arti Shukla Studies Methods for Early Detection of Mesothelioma
• In Focus: Melanoma Research Funding
• Advancing Our Understanding of How to Reduce the Risk of Developing Blood Cancer After Radiation Exposure
• An Improved Toolset for Pancreatic Cancer Research
• Investigating the Link between Cancer Formation and Cell Reprogramming
• IN FOCUS: STOMACH CANCER RESEARCH FUNDING
• IN FOCUS: LIVER CANCER RESEARCH FUNDING
• Giving Mesothelioma the One-Two Punch
• Discovering novel therapeutic strategies to treat kidney cancer
• Targeting Fibroblast Growth Factor Receptor Signaling Pathways in Mesothelioma
• Identification of Novel RNA Editing Biomarkers of Human Leukemia Stem Cell Generation
• Linking Observed Mutations from Pediatric Brain Tumors to Mechanisms That May Drive Tumorigenesis
• Understanding Inflamation and Its Link to Colorectal Cancer

Peer Reviewed Medical:

• Mitigating the Effects of Acute and Delayed Radiation Exposure to Hematopoiesis and Blood Stem Cell Function Using the Prostaglandin E2 Signaling Cascade
• Novel Liver-Stage-Active Antimalarials
• A Novel Host-Protein Point of Need Platform for Differentiating Bacterial Versus Viral Infections: Transition from Prototype to Product
• Amicidin-α Surgical Gel for Prevention of Infections in Surgery and Trauma
• Novel RNAi Ovitraps to Protect Service Members from Mosquito-Borne Illnesses
• Development of Novel Pain Medications from Marine Sources to Replace Opioids
• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Investigating the Cellular and Molecular Mechanisms Associated with Worsened Outcomes in COVID-19 Patients with Chronic Lung Disease
• Development of BIO 301: An Encapsulated Nanogenistein Therapy
• Peer Reviewed Medical Research Program Releases Funding Opportunities for COVID-19 Research
• Research with a Comprehensive Impact
• Taking Ideas From Discovery to the Clinic
• Improving Medical Care for Service Members and Their Families
• Mesenchymal Stem Cell Transplantation as a Therapeutic Agent for Multiple Sclerosis
• Adoptive Cellular Therapy Targeting Recurrent Pediatric Brain Cancers
• Guiding Therapeutic Decisions for Patients Using microRNA Biomarkers
• Developing a Fingerprint for Renal Cell Carcinoma Progression
• Making a difference in congenital heart disease
• Engineering Immunotherapies for Mesothelioma and Other Solid Tumors

Peer Reviewed Orthopaedic:

• Early Data Suggests a Potential New Bioengineering Strategy for Treating Osteoarthritis
• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Development of Large Animal Models for Improved Regenerative Therapies in Bone Healing and Volumetric Muscle Loss Injury
• Seeking Multimodal Vaccines to Eradicate Biofilm-Associated Microorganisms Following Traumatic Musculoskeletal Injury
• New Information in Our Understanding of Osteoarthritis Onset
• CPT Matthew Anderson – Advocating for Change
• Focusing on Optimal Recovery and Restoration for our Servicemembers
• Neuroma/Targeted Muscle Reinnervation Educational Highlight
• Development of a High-Performance, Adaptable Prosthetic Socket for Amputees
• Experimental PEG Fusion Medical Device for Immediate Physiological Recovery After Peripheral Nerve Injury
• Development of an Active Cooling System for Improving Residual Limb Skin Care
• New Large Animal Model to Study Treatment for PTOA
• siRNA Delivery to Stem Cells in the Treatment of Post-Traumatic Osteoarthritis
• Providing upper-extremity prosthetic device users with functionality and flexibility

Prostate Cancer:

• Active Surveillance for African-American Men with Prostate Cancer
• Combining Nanotechnology and Radiation to Enhance Checkpoint Blockade Immunotherapy of Advanced Prostate Cancer
• The Impact of a Gene Expression Profile on Treatment Choice and Outcome among Minority Men Newly Diagnosed with Prostate Cancer
• Effects of CD24/RCC2/p53 Signaling on Prostate Cancer Metastasis
• Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer
• Characterization of the Immune-Oncologic Profile of Lethal Prostate Cancer in African American Men
• Alleviating Immunosuppression to Enhance CAR T-Cell Efficacy in Metastatic Prostate Cancer
• Identifying Genomic Drivers of Prostate Cancer Progression
• Investigating Racial Differences in the Financial Impact of Prostate Cancer
• Preserving Sexual Function in Men Undergoing Radiation Treatment for Prostate Cancer
• High dose testosterone causes DNA damage and suppresses prostate cancer growth
• Bipolar Androgen Therapy: Breaking Out of the Chrysalis of Chronic Androgen Deprivation Therapy in Men with Late-Stage Castrate-Resistant Prostate Cancer
• The Prostate Cancer Clinical Trials Consortium: Addressing Health Disparities by Increasing Diversity in Clinical Trials
• BET Bromodomain Degraders for the Treatment of Metastatic Prostate Cancer
• Using a novel genetically engineered mouse model to identify new drug targets for treatment-resistant metastatic prostate cancer
• First-in-Class Anti-sMIC Immunotherapy Antibody Therapy to Target Prostate Cancer Metastasis
• Artificial Lymph Node: A Trap to Study and Fight Prostate Cancer
• Targeting BET proteins in Prostate Cancer
• Synergistic Action of FOXP3 and TSC1 Pathways in Prostate Cancer Progression
• Revolutionizing prostate cancer imaging with collagen hybridizing peptide
• Assessment of Biospecimen Needs of the Prostate Cancer Research Community
• The PROPHECY Study Validates the Use of Two AR-V7 Biomarker Assays for Predicting Hormone Therapy Resistance in Men with Metastatic Castration-Resistant Prostate Cancer
• NEK6 mediates castration resistance in prostate cancer in vivo
• LSD1: a novel biomarker and therapeutic target for prostate cancer
• Assessment of Biospecimen Needs of the Prostate Cancer Research Community
• Deconvoluting the Complexity of Bone Metastatic Prostate Cancer via Computational Modeling
• Combining Metformin with Androgen Deprivation Therapy to Treat Advanced Prostate Cancer
• Clinical Implications for Long Non-coding RNAs in Prostate Cancer
• CDK12 loss is a distinct immunogenic class of advanced prostate cancer
• Autonomic Nerves Drive Prostate Cancer Growth, Invasion, and Metastasis
• Inhibition of ACK1 to Overcome Drug Resistance in Prostate Cancer
• A Relationship Between Mast Cells and Racial Disparity of Prostate Cancer
• Chimeric Amino Acid Rearrangements as Immune Targets in Prostate Cancer
• Dr. Bettina Drake Video - Prostate Cancer Outcomes in VA Hospitals
• Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer
• Circulating tumor cell analysis as a treatment-specific biomarker for prostate cancer
• Targeting the Aberrant Androgen Receptor in Advanced Treatment-Resistant Prostate Cancer
• Statin use may increase survival in men with prostate cancer undergoing androgen deprivation therapy
• Cooperativity between Oncogenic PKC Epsilon and Pten Loss in Prostate Cancer

Psychological Health and Traumatic Brain Injury:

• Preparing for Future Battlefield Contestations by Maximizing Medical and Prolonged Field Care Methods in the Operational Environment
• Effect of Prolonged Exposure Therapy on PTSD Symptom Severity in Military Personnel
• Predicting Generalized Anxiety Among Military Couples Following Deployment
• A Military-Relevant Model of Closed Concussive Head Injury: Longitudinal Studies Characterizing and Validating Single and Repetitive mTBI
• Genetic and Environmental Predictors of Combat-Related PTSD/The STRONG STAR Multidisciplinary PTSD Research Consortium
• The TBI Endpoints Development (TED) Initiative Advances Multidisciplinary Research Efforts to Improve Diagnosis and Treatment of TBI
• THE NCAA-DOD GRAND ALLIANCE: Concussion Assessment, Research, and Education Consortium (CARE)
• TEAM-TBI: a Precision Medicine Approach for TBI
• CENC Researchers Blaze a Trail to New Insights in Mild Traumatic Brain Injury
• The INjury and TRaumatic STress (INTRuST) Clinical Consortium Neuroimaging Leadership Core
• Operation Brain Trauma Therapy: Consortium Identifies Promising New Treatments and Biomarkers for Traumatic Brain Injury
• The INjury and TRaumatic STress (INTRuST) Clinical Consortium Brings Together Scientists to Further Posttraumatic Stress Disorder (PTSD) and Traumatic Brain Injury (TBI) Research
• Treatment of Adult Severe Traumatic Brain Injury Using Autologous Bone Marrow Mononuclear Cells
• Treatment of TBI with Hormonal and Pharmacological Support, Preclinical Validation Using Diffuse and Mechanical TBI Animal Models
• Building a Family Systems Model to Promote Adherence to PTSD Treatment
• Is telemedicine-delivered therapy as effective as treatment delivered at the clinic?
• Defining the Impact of Group Therapy on Treating PTSD in Active Military Personnel

Rare Cancers:

• Partnering with patients to create a rare soft tissue sarcoma target discovery platform as a community resource

Reconstructive Transplant Research:

• Mapping the Inflammatory Response to Vascularized Composite Allotransplantation
• Transfer of Donor Lymph Nodes to Promote Graft Tolerance
• Engineered Microparticles for Promoting Transplant Tolerance: Taking a Page Out of Cancer’s Playbook
• Increasing Organ Donor Authorization for Vascularized Composite Allotransplantation
• Improving and Quantifying Functional Hand Use in Hand Transplant Recipients and Amputees
• CDMRP-funded Physician Performs Historic Face Transplant Surgery
• Project Update: Biomarkers to Predict Rejection in Vascularized Composite Allotransplantation: MMP3
• Reconstructive Transplant Research Program (RTRP) Request for Information (RFI)
• Developing Therapeutic Reagents to Accelerate the Rate of Peripheral Nerve Growth after Reconstructive Transplantation
• Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation via Histone Deacetylase Modulation
• T-Regulatory Cell-Based Therapies Promote Survival of Vascularized Composite Allografts
• Biomarkers to Predict Rejection in Vascularized Composite Allotransplantation
• Utilizing Vascularized Bone to Improve Outcomes of Face Transplantation

Scleroderma:

• Preparing the Way for New Investigators While Fostering High-Impact Research: The Scleroderma Research Program’s Idea Development Award — New Investigator Collaboration Option

Spinal Cord Injury:

• Perspectives for Robotic Exoskeleton Use in Persons with Spinal Cord Injury Across Rehabilitative and Community Settings
• Update on TRACK-SCI: Toward Better Biomarkers and Data Accessibility for Spinal Cord Injury Research
• Stentrode: A SCIRP-Funded Device to Facilitate Independence After Paralysis
• TRACK-SCI: Leveraging Fundamental Clinical Discoveries to Guide Treatment and Improve Recovery after Spinal Cord Injury
• Acute Intermittent Hypoxia as a Multi-Functional Therapy for Spinal Cord Injuries
• Efficacy Study of a Fully Implanted Neuroprosthesis for Functional Benefit to Individuals with Tetraplegia
• Utilizing Nerve Transfers to Improve Hand Function Following Cervical Spinal Cord Injury
• Treatment of Sleep Apnea in Patients with Cervical Spinal Cord Injury
• Directing Spinal Cord Plasticity: The Impact of Stretch Therapy on Functional Recovery After Spinal Cord Injury
• A Randomized, Crossover Clinical Trial of Exoskeletal-Assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons with SCI
• Restoring Proprioception via a Cortical Prosthesis: A Novel Learning-Based Approach
• Managing the acute spinal cord injury
• Introducing the FY15 Spinal Cord Injury Research Program Portfolio
• An Implantable Neuroprosthetic Device to Normalize Bladder Function after Spinal Cord Injury
• Experiences of Living with Pain after a Spinal Cord Injury

Tick-Borne Disease:

• A Pre-Exposure Immunoprophylaxis for the Prevention of Lyme Disease
• Lyme Disease Awareness Month – Spotlight on TBDRP FY19 Lyme Disease Initiatives
• Generation of a Vaccine Candidate to Protect Against Tick-Borne Ehrlichiosis
• Lyme Disease Awareness Month – Spotlight on TBDRP FY18 Lyme Disease Initiatives
• Scientist Working to Improve Diagnosis of Lyme Disease and Other Tick-Borne Illnesses
• Lyme Disease Awareness Month - Spotlight on TBDRP FY17 Lyme Disease Initiatives

Traumatic Brain Injury and Psychological Health:

• CDMRP supports Sexual Assault Prevention and Response Research on Behalf of the Department of Defense

Tuberous Sclerosis Complex:

• A Timeline for Success: The FDA Approves New Topical Treatment for Facial Tumors in TSC
• Autophagy and the Neurocognitive Deficits in TSC
• Developing Novel mTORC1 Inhibitors to Treat TSC
• Genetic Analysis of TSC Tumors Identifies Novel Therapeutic Targets
• Neural Circuits Underlying Autism Relevant Behaviors in TSC
• TSC Remote Assessment and Intervention (TRAIN)
• Targeting Autophagy for the Treatment of TSC and LAM
• Inhibition of Neuron Hyperexcitability In The TSC Brain May Provide A Therapeutic Option To Treat Seizures
• Causes of Epilepsy in TSC- Potential Therapeutic Targets
• Identifying Mechanisms Initiating LAM and Angiomyolipoma in Tuberous Sclerosis Complex
• Metabolic Imaging Biomarkers for TSC
• Repurposing FDA-Approved Drugs to Treat Tuberous Sclerosis Complex
• Gene Therapy, a New Approach to Treating TSC
• Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex
• Modeling TSC and LAM Using Patient-Derived Induced Pluripotent Stem Cells
• A Novel Model Provides Insight into Tuberous Sclerosis Complex
• A Promising Early Intervention for TSC linked Autism in Infants
• Building Protein Network Models of Epilepsy to Find New Treatments in TSC
• Understanding the Mechanisms of Disease Leads to Potential New Treatments for TSC-related LAM
• Identifying the Roots of Myelin Dysfunction in the TSC Brain
• Inflammation and Epilepsy in TSC
• Targeting Amino Acid-mTORC1 Signaling for Treatment of TSC
• Loss of Tsc2 and Increased mTORC1 Signaling in Excitatory Neurons Lead to Complex Abnormalities
• TSC-FoxO Signaling Network in Kidney Cancer Development

Vision:

• CAPT Walter Steigleman, MD - Advancing Research for Military Vision Trauma
• MAJ Thomas Zampieri (USA Ret.), PhD, PA - Restoring Hope for Service Members with Eye Trauma
• Michael Steinmetz, PhD - Generating New Treatments for Warfighters and Their Families
• COL Mark Reynolds, MD - Addressing the Unique Challenges of Military Eye Trauma
• USC Team Captures Valuable User Feedback from Military Medical Personnel regarding Novel Reversible Adhesive to Manage Ocular Trauma
• Computational Modeling of Primary Blast Injury to the Eye
• A Retinal Prosthetic with the Capacity to Produce Normal Vision

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