DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

The NFRP now offers a service on our website featuring a listing of available NF research resources!! Our goal is to facilitate and speed NF research by publicizing new resources and aiding collaborations. The list displays available resources and repository or PI contact information. Please contact the repository or PI directly for information and requests.

Award Number PI Product or Resource References Contact Information or Link
Mouse Models

NF130064

Aaron Schindeler

Nf1MyoD-/-, Nf1Prx1-/-, Nf1iPax7-/-

Sullivan K, El-Hoss J, Quinlan KGR, et al. NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics. 2014;23(5):1250-1259.

aaron.schindeler@sydney.edu.au

NF093074

Slawomir Antoszczyk

MPNST sciatic nerve sheath tumor model in immune competent mice

Antoxzczyk S, et al. 2014. Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus. Neuro Oncol, first published online January 26, 2014

SANTOSZCZYK@mgh.harvard.edu

NF093053

Nancy Ratner

PlpCre;Nf1 flox/flox

Mayes DA, et al. 2011 Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer Research 71(13):1-11.

Please contact both Drs. Nancy Ratner (nancy.ratner@cchmc.org) and Luis Parada (luis.parada@utsouthwestern.edu).

NF080045

Kevin Pumiglia

Inducible knockdown of Nf1 in the vascular endothelium: CAD5-CreERT2/Rosa26-LSL-td-Tomato/NF1flox/flox

Bajaj A et al. 2012. Loss of NF1 Expression in Human Endothelial Cells Promotes Autonomous Proliferation and Altered Vascular Morphogenesis. PLoS ONE 7(11): e49222.

pumiglk@mail.amc.edu

NF080017

Florent Elefteriou

Nf1 loss of function in chondrocytes

Wang W, et al. 2011. Mice lacking Nf1 in osteochondroprogenitor cells displays skeletal dysplasia similar to patients with neurofibromatosis type 1. Human Molecular Genetics 20(20):3910-3924.

florent.elefteriou@bcm.edu

NF073112

Feng-Chun Yang

NF1 skeletal model with reduced bone mineral density, reduced calcium ossification, reduced bone turnover, and increased ratio of spinal canal area to vertebral body area

Xiaohua W, et al. 2011. The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis Type 1. Public Library of Science 6(9):e24917.
doi.10.1371/journal.pone. 0024917

fyang@iupui.edu

NF043040

Andrea McClatchey

Model of renal carcinoma: Vil-Cre; Nf2lox/lox

Morris ZS, et al. 2009. Aberrant epithelial morphology and persistent EGFR signaling in a mouse model of renal cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America 106(24):976-982.

mcclatch@helix.mgh.harvard.edu

NF043050
NF010093

Tyler Jacks

Paternal inheritance of Nestin-Cre resulting in mosaic loss of Nf2: NesCreP; Nf2flox/flox

McLaughlin ME, et al. 2007. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proceedings of the National Academy of Sciences of the United States of America 104(9):3261-3266.

tjacks@mit.edu

NF010093
NF990018

Kevin Shannon

Model of myeloproliferative disorder: Mx1-Cre; Nf1flox/flox

Le DT et al. 2004. Somatic inactivation of NF1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood 103(11):4243-4250.

ShannonK@peds.ucsf.edu

NF010016

Marco Giovannini

  1. Protein 4.1Bflox/flox
  2. Protein 4.1B+/-
  3. Protein 4.1B-/-

Mcclatchey AI and Giovannini M. 2005. Membrane organization and tumorigenesis-the NF2 tumor suppressor, Merlin. Genes Dev 19(19):2265-2277.

mgiovannini@hei.org

NF960044

Luis Parada

Conditional knockout of Nf1: Nf1 flox/flox
Conditional knockout of Nf1 in neurons: Synapsin 1-Cre; Nf1flox/flox

Zhu Y et al. 2001. Ablation of NF1 function in neurons induces abnormal brain development of cerebral cortex and reactive gliosis in the brain. Genes & Development 15(7):859-876.

http://mouse.ncifcrf.gov/available_details.asp?ID=01XM4 (external link)

NF960044

Luis Parada

Nf1+/-; p53+/- cis

Vogel KS, et al. 1999. Mouse tumor model for neurofibromatosis type 1. Science 286(5447):2176-2179.

http://jaxmice.jax.org/strain/008191.html (external link)

NF960041

Tyler Jacks

Nf1+/-; p53+/- cis

Cichowski K, et al. 1999. Mouse models of tumor development in neurofibromatosis type 1. Science 286(5447):2172-2176.

http://jaxmice.jax.org/strain/008191.html (external link)

NF960041

Tyler Jacks

Model of glioblastoma: Nf1 +/-; Trp53 +/-

Reilly KM et al. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genetics 26(1):109-113.

tjacks@mit.edu

NF960041

Tyler Jacks

Nf2 +/-; p53 +/-

McClatchey AI et al. 1998. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes & Development 12(8):1121-1133.

tjacks@mit.edu

NF960018

Nancy Ratner

Nerve wounding model and skin carcinogenesis model supporting a role for NF1 in epithelial carcinogenesis.

Atit RA, Mitchell K, Nguyen L, Warshawsky D, and Ratner N. 2000. The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57B1/6 mice. J. Invest. Dermatol., 114:1092-1100.

Atit RP, Crowe MJ, Greenhalgh DG, Wenstrup RJ, Ratner N. 1999. The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts. J Invest Dermatol. Jun;112(6):835-42.

nancy.ratner@cchmc.org