DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS

The NFRP now offers a service on our website featuring a listing of available NF research resources!! Our goal is to facilitate and speed NF research by publicizing new resources and aiding collaborations. The list displays available resources and repository or PI contact information. Please contact the repository or PI directly for information and requests.

Award Number PI Product or Resource References Contact Information or Link
Zebrafish Models

NF130052

Michael Granato

nf1a+/-; nf1b-/- exhibiting memory and learning deficits

Wolman et al. 2014. Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1. Cell Report; 8: 1265-1270.

granatom@mail.med.upenn.edu

NF050175

Jonathan Epstein

Zebrafish lines harboring stable germline mutations in nf1a and nf1b

Lee JS, Padmanabhan A, Shin J, et al. 2010. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet.19(23):4643-53.

Shin J, Padmanabhan A, de Groh E, et al. 2012. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech 5(6):881-894.

Wolman et al. 2014. Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1. Cell Report; 8: 1265-1270.

Zhu et al. 2011. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development. 138(20):4555-64.

http://zfin.org/

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