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A large majority of the injuries sustained by military personnel in U.S. combat efforts involve soft tissue wounds and skeletal fractures, pointing to an urgent need for orthopaedic research that will provide superior medical care and treatment options for injured Service members. Orthopaedic injuries sustained during combat-related activities tend to be heterogeneous and complex in nature, typically involving multiple tissues, such as skin, bone, muscle, cartilage, and nerves. These injuries are sustained in harsh environments where access to optimal acute care can be limited, and they are distinct from those seen in the civilian setting, frequently involving multiple limb trauma, open fractures, major tissue loss, and a high degree of wound contamination. The Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP) was established by Congress in fiscal year 2009 (FY09) to support military-relevant, peer-reviewed orthopaedic research with potential to provide healthcare solutions for the injured Service member, Veteran, and civilian.